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维生素D与自身免疫性甲状腺疾病的研究进展

蔺亚斌 兰丽珍

030000 太原,山西医科大学1;030000 太原,山西医科大学第一医院内分泌科2

兰丽珍,Email: lanlizhen@163.com

摘 要:自身免疫性甲状腺疾病(AITD)是一种T淋巴细胞介导的器官特异性自身免疫性疾病,主要包括桥本甲状腺炎(HT)和Grave病(GD),其发病机制尚不明确,可能与遗传、环境及免疫等有关。维生素D除具有调节骨和钙磷代谢,防治骨质疏松外,近年研究发现维生素D可能通过影响T淋巴细胞的增殖与分化,参与免疫调节,维持免疫内稳态。本文综述维生素D与AITD相关性的研究进展,旨在为AITD的预防与治疗提供新的思路。

关键词:维生素D; 维生素D受体; 自身免疫性甲状腺疾病

Research progress of vitamin D and autoimmune thyroid disease

Lin Yabin1, Lan Lizhen2.

1Shanxi Medical University, Taiyuan 030000, China; 2Department of Endocrinology, the First Hospital of Shanxi Medical University, Taiyuan 030000, China

Lan Lizhen, Email: lanlizhen@163.com

Abstract:Autoimmune thyroid disease (AITD) is a kind of organ specific autoimmune disease mediated by T lymphocytes cell, most including Hashimoto thyroiditis (HT) and Grave disease (GD). Its pathogenesis is still unclear, being related to genetic, environmental and immune etc. Vitamin D (VD) can adjust metabolism of bone, calcium and phosphorus, preventing and treating osteoporosis. Some studies in recent years found that VD also plays a important role of immune regulation and immunologic homeostasis by affecting proliferation and differentiation of T lymphocytes. This article reviewed in the relationship between VD and AITD, in order to provide a new way of thinking for the prevention and treatment of AITD.

Key words:Vitamin D; Vitamin D receptor; AITD

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文献标引:蔺亚斌 兰丽珍.维生素D与自身免疫性甲状腺疾病的研究进展[J/CD].中华临床医师杂志:电子版,2017,11(4):667.

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