中华临床医师杂志(电子版) 2017年2月,11卷4期

临床论著

胃食管反流病的特点及与牙周疾病相关性研究

古孜努尔·阿巴斯1,2 米尔阿迪力·阿布都卡迪尔2 木合塔尔·霍加2

830000 乌鲁木齐,新疆医科大学研究生学院1;830000 乌鲁木齐,新疆维吾尔自治区人民医院口腔科2
木合塔尔·霍加,Email: muhtarhoja@aliyun.com

摘要:目的 探讨胃食管反流病(GERD)的流行病学特点及与牙周疾病之间的关系。方法 对于2014年4月至2016年4月就诊于新疆维吾尔自治区人民医院口腔科的80例GERD患者和71名正常人进行GERD相关检查和牙周疾病检查,牙周检查以社区牙周指数(CPI)和附着丧失(AL)作为诊断标准。结果 GERD患者与对照组比较,年龄、性别等指标之间无统计学差异(P>0.05),而民族、BMI、吸烟比例等指标之间有统计学差异(P<0.05),GERD患者中维吾尔族较汉族多(χ2=4.447,P=0.035),BMI高于对照组(t=2.463,P=0.015),GERD组吸烟比例较对照组高(χ2=5.234,P=0.022),GERD患者牙周炎患病率较对照组高(χ2=4.113,P=0.043),在GERD患者中牙周炎严重程度较对照组高。通过Logistics回归分析可知年龄是牙周炎的危险因素(OR=1.091,95% CI 1.052~1.132),非GERD(OR=0.332,95% CI 0.176~0.624)和不吸烟(OR=0.422,95% CI 0.210~0.847)是牙周疾病的保护因素。结论 与吸烟、年龄等危险因素一样,GERD是牙周疾病的危险因素之一。

关键词:胃食管反流; 牙周疾病; 治疗,临床研究性

Study on the correlation between gastroesophageal reflux disease and periodontitis

Guzinuer abasi1,2, Mieradili abudukadier2, Muhetaer huojia2.

Graduate School of Xinjiang Medical University, Urumqi 830000, China; 2Department of Stomatology, Xinjiang People's Hospital, Urumqi 830000, China
Muhetaer huojia, Email: muhtarhoja@aliyun.com

Abstract:Objective To investigate the epidemiological characteristics of gastroesophageal reflux disease (GERD), and the correlation with the periodontitis. Methods 80 GERD patients and 71 healthy people were selected dated from April 2014to April 2016, all patients were given periodontal examination according to the diagnostic criteria of community periodontal index (CPI) and attachment loss level (AL). Results There was no statistically significant differences among the age and gender between GERD group and comparative group, but statistically significant differences existed among the nationality, BMI index and smoking proportion. Prevalence of periodontal disease was higher in the GERD group than the comparative group, the severity of periodontal disease kept increasing rate in the GERD group than the control group, Logistic regression analysis indicated that the age was the risk factor of periodontitis, the not smoking and not GERD was the protect factor for periodontitis. Conclusion The GERD disease is one of the risk factor of periodontitis.

Keywords:Gastroesophageal reflux; Periodontal diseases; Therapies, investigational

+ 字体 -

参考文献

  [1] Song JY, Kim HH, Cho EJ, et al. The relationship between gastroesophageal disease and chronic periodontitis[J]. Gut Liver, 2014, 8(1): 35-40.

  [2] Iwata T, Yamato M, Ishikawa I, et al. Tissue engineering in periodontal tissue[J]. Anat Rec (Hoboken), 2014, 297(1): 16-25.

  [3] 卞金有. 口腔预防医学[M]. 3版: 北京: 人民卫生出版社, 2002: 36.

  [4] Wang J, Zhang R, Shen Y, et al. Recent Advances in Cell Sheet Technology for Periodontal Regeneration[J]. Curr Stem Cell Res Ther, 2014, 9(3): 162-173.

  [5] Abou Neel EA, Chrzanowski W, Salih VM, et al. Tissue engineering in dentistry[J]. J Dent, 2014, 42(8): 915-928.

  [6] Moraes-Filho JP. Refractory gastroesophageal reflux disease[J]. Arq Gastroenterol, 2012, 49(4): 296-301.

  [7] Dzhamaldinova TD. Dynamics of inflammatory periodontal disease under the influence of gastroesophageal reflux disease therapy[J]. EKSp Klin Gastroenterol, 2010(8): 46-51.

  [8] Domingues GR, Moraes-Filho JP, Domingues AG. impact of prolonged 48-h wireless capsule esophageal PH monitoring in diagnosis of gastrophageal reflux disease and evaluation of the relationship between symptoms and reflux episodes[J]. Arq Gastroenterol, 2011, 48(1): 24-29.

  [9] Adachi K, Mishiro T, Tanaka S, et al. A study on the relationship between reflux Exophagitis and Periodontitis[J]. Intern Med, 2016, 55(18): 2523-2528.

(编辑:梁雷 收稿日期:2016-11-01)