中华临床医师杂志(电子版) 2017年2月,11卷4期

综 述

利用免疫缺陷动物构建骨肉瘤动物模型研究进展

张龙 葛乔枫 吕智

030000 太原,山西医科大学第二医院骨科
吕智,Email: zhilv2013@163.com

摘要:骨肉瘤是骨组织最常见的原发性恶性肿瘤,恶性程度很高且青少年多发,目前其机制尚不明确,故构建一个生物学行为和药物动力学接近人骨肉瘤的动物模型是深入研究该疾病发病机制、寻找靶向性和特异性更高的新治疗手段的重要途径。免疫缺陷动物是先天性遗传突变或人工方法造成的一种多系统免疫功能缺陷动物,裸鼠因其无胸腺和T细胞缺如的免疫缺陷特点,使移植性肿瘤仍能保留其原有的生物学特性,成为直接研究人类骨肉瘤生物学特性及其发病机制的重要研究手段。现就近年免疫缺陷动物的骨肉瘤动物模型建立作一综述。

关键词:骨肉瘤; 模型,动物; 移植; 裸鼠

Research progress of using immunodeficiency animal in osteosarcoma animal model establishment 

Zhang Long, Ge Qiaofeng, Lyu Zhi.

Department of Orthopedics, the Second Hospital of Shanxi Medical University, Taiyuan 030000, China
Lyu Zhi, Email: zhilv2013@163.com

Abstract:Osteosarcoma is the most frequent malignant primary bone tumor in childhood and adolescence, but its mechanism is not clear at present. Establishing an animal model of osteosarcoma with biological behavior and pharmacokinetics close to human osteosarcoma is the significant approach, not only to learn the pathogenesis, but also to seek therapies with specific targeting property. Immunodeficiency animal is a kind of multisystem immune deficiency animal caused by congenital genetic mutation or artificial method. Nude mice, without thymus and T cell, keeping the biological characteristics of transplanted tumor, have become the primary study tool to research biological characteristics of transplantation model of human osteosarcoma in recent years. This review introduced the progress of animal models of osteosarcoma over the last years.

Keywords: Osteosarcoma; Models, animal; Transplantation; Nude mouse

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(编辑:戚红丹 收稿日期:2016-11-14)