中华临床医师杂志(电子版) 2017年2月,11卷4期

短篇论著

极年轻胃癌患者的胃镜表现、临床病理特征与预后分析

杨霞 章宏 杜爱民 毛勇

200052 上海,解放军八五医院消化内科
杜爱民,Email: Dam85@163.com

摘要:目的 研究极年轻(年龄<35岁)胃癌患者这一特定人群的胃镜表现、临床病理特点和预后。方法 收集2000年1月至2010年12月上海解放军八五医院收治的108例极年轻胃癌患者的临床资料为试验组,对照组为同时期本院收治的年龄>35岁的中老年胃癌患者,对比两组患者的一般情况、主要临床症状、胃镜表现以及病理结果、生存期等,根据数据分类的不同采用卡方检验和t检验进行对比分析。结果 试验组的108例极年轻患者中,中位年龄为31岁,其中60.2%为女性患者,35.2%的患者临床表现有报警症状,19.4%的患者有胃癌家族史。59.3%的患者肿瘤位于胃体,32.4%的患者位于胃窦。64.8%的患者肿瘤为弥散型;这些临床特征与对照组的中老年(年龄>35岁)胃癌患者相比差异均有统计学意义(P<0.05)。19.4%的试验组患者进行了外科切除手术,其5年生存率为42.1%。与行外科手术的对照组患者相比,两者的生存率相比差异无统计学意义(P>0.05)。结论 极年轻胃癌患者以女性为主,临床表现很少有报警症状,但是这些患者中有胃癌家族史的较多,大部分胃癌位于胃体,行根治性外科手术后的患者其长期生存率与中老年胃癌患者相当。

关键词:胃肿瘤; 胃镜; 极年轻; 临床表现; 预后

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(编辑:马超 收稿日期:2016-04-19)